Kim Sung-Jun, Kim Jae-Sung, Cho Hong-Suk, Lee Hyo Jung, Kim Sang Yong, Kim Seung, Lee Sook-Young, Chun Hong Sung
Department of Biotechnology, Research Center for Proteineous Materials, Chosun University, Gwangju, Republic of Korea.
Neuroreport. 2006 Nov 6;17(16):1729-33. doi: 10.1097/01.wnr.0000239951.14954.10.
Carnosol, a major component of Rosmarinus officinalis, is a phenolic diterpene that has potent antioxidant and anti-inflammatory activities. In this study, we investigated the protective effects of carnosol on rotenone-induced neurotoxicity in cultured dopaminergic cells. Results showed that cell viability was significantly improved with carnosol through downregulation of caspase-3. Furthermore, carnosol significantly increased the tyrosine hydroxylase, Nurr1, and extracellular signal-regulated kinase 1/2. These results suggest that carnosol may have potential as a possible compound for the development of new agents to treat Parkinson's disease.
鼠尾草酸是迷迭香的主要成分，是一种具有强大抗氧化和抗炎活性的酚类二萜。在本研究中，我们研究了鼠尾草酸对鱼藤酮诱导的培养多巴胺能细胞神经毒性的保护作用。结果表明，鼠尾草酸通过下调半胱天冬酶 - 3显著提高了细胞活力。此外，鼠尾草酸显著增加了酪氨酸羟化酶、Nurr1和细胞外信号调节激酶1/2。这些结果表明，鼠尾草酸可能具有开发治疗帕金森病新药的潜在价值。
