单次应用抗风湿药金诺芬后人体中金的全身消除途径。

Whole body elimination routes of gold in humans after a single-dose application of the antirheumatic auranofin.

作者信息

Schnier C, Benn H P

机构信息

Institute of Physics, GKSS Research Centre, Geesthacht, FRG.

出版信息

Biol Trace Elem Res. 1990 Jul-Dec;26-27:471-7. doi: 10.1007/BF02992702.

DOI:10.1007/BF02992702

PMID:1704752

Abstract

After removal of the gallbladder (cholecystectomy) 7 patients were administered the antirheumatic agent Auranofin in its commercially available tablet form (Ridaura) 3 d postoperative. The single dose consisted of 5 tablets (4.35 mg of gold). Gold was determined in samples of blood, plasma, urine, bile, and feces (1-2 mL and 2.5 g, respectively). The specimens were drawn 10 min to 8 d p.a. and on d 14 p.a. The determinations were performed by instrumental neutron activation analysis (INAA). The limit of detection was less than 1 ng of gold. The courses of the mean gold concentrations show maxima after 1.9 h in blood and plasma, and after 16 h in urine and bile. The mean half-lives (terminal phases) are 7.6 d (blood), 23 d (plasma), and 6.5 d (bile).

摘要

在切除胆囊（胆囊切除术）后，7例患者在术后第3天服用了市售片剂形式的抗风湿药金诺芬（瑞得）。单次剂量为5片（4.35毫克金）。在血液、血浆、尿液、胆汁和粪便样本中测定金含量（分别为1 - 2毫升和2.5克）。在术后10分钟至8天以及术后第14天采集样本。通过仪器中子活化分析（INAA）进行测定。检测限低于1纳克金。平均金浓度曲线显示，血液和血浆中的金浓度在1.9小时后达到最大值，尿液和胆汁中的金浓度在16小时后达到最大值。平均半衰期（终末相）分别为血液7.6天、血浆23天和胆汁6.5天。