Benn H P, Schnier C, Seiler K U, Bauer E, Löffler H
2nd Department of Internal Medicine, University of Kiel, West Germany.
J Rheumatol. 1990 Apr;17(4):466-8.
Three days after cholecystectomy 7 patients were given a single dose of auranofin (5 tablets Ridaura = 4.35 mg gold). Gold was detected in samples of blood, plasma, urine, bile and feces. The determinations were carried out using instrumental neutron activation analysis. The mean gold concentrations reached maximum in blood and plasma after 2 h and in urine and bile after 16 h. The mean terminal half-lives were 7.6 days (blood), 15 days (plasma) and 6.5 days (bile). Cumulative amounts of gold excreted in bile, urine, and feces were 1.6, 4 and 40%, respectively.
胆囊切除术后三天，给7名患者单次服用一剂金诺芬（5片瑞得 = 4.35毫克金）。在血液、血浆、尿液、胆汁和粪便样本中检测到了金。使用仪器中子活化分析法进行测定。血液和血浆中的平均金浓度在2小时后达到最高，尿液和胆汁中的平均金浓度在16小时后达到最高。平均终末半衰期分别为血液7.6天、血浆15天和胆汁6.5天。胆汁、尿液和粪便中排泄的金的累积量分别为1.6%、4%和40%。
