Yu Qiong, Wang Hailian, Chen Jun, Gao Yanqin, Liang Weimin
Department of Anesthesiology of Huashan Hospital, affiliated with Fudan University, Shanghai, China.
Front Biosci (Elite Ed). 2010 Jun 1;2(4):1275-98. doi: 10.2741/e189.
The new generation of inhalational anesthetics has been widely used for general anesthesia in both clinical and experimental settings because of their safety, reliability and potency. A neuroprotective role has recently been revealed for some of these anesthetics, including the volatile gases isoflurane, sevoflurane, and desflurane, as well as the inert gas xenon. In vivo and in vitro studies have demonstrated that these gases were able to protect brain against ischemic injury, indicated by the decreases in infarct volumes and neuronal apoptosis. In this review, we [Please see table 1] will briefly introduce the properties of these gases, and discuss in detail their effects on brain ischemia, effective treatment regimens, and neuroprotective mechanisms. Perspectives are also discussed on future study and use of inhalational anesthetics.
新一代吸入性麻醉剂因其安全性、可靠性和效能，已在临床和实验环境中广泛用于全身麻醉。最近发现其中一些麻醉剂具有神经保护作用，包括挥发性气体异氟烷、七氟烷和地氟烷，以及惰性气体氙。体内和体外研究表明，这些气体能够保护大脑免受缺血性损伤，表现为梗死体积减小和神经元凋亡减少。在本综述中，我们[请见表1]将简要介绍这些气体的特性，并详细讨论它们对脑缺血的影响、有效治疗方案和神经保护机制。还讨论了吸入性麻醉剂未来研究和应用的前景。
