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The Baylis-Hillman approach to quinoline derivatives.

作者信息

Familoni Oluwole B, Klaas Phindile J, Lobb Kevin A, Pakade Vusumzi E, Kaye Perry T

机构信息

Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa.

出版信息

Org Biomol Chem. 2006 Nov 7;4(21):3960-5. doi: 10.1039/b608592j. Epub 2006 Sep 25.

DOI:10.1039/b608592j
PMID:17047876
Abstract

Baylis-Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo- and regioselectivity of cyclisation appears to be influenced by the choice of both the substrate and the reagent system, and competing reactions have been observed.

摘要

相似文献

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引用本文的文献

1
A convenient one-pot preparation of 2-methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman adducts and their oxidation to the corresponding sulfones.从 Morita-Baylis-Hillman 加合物出发，通过一锅法简便制备 2-甲基-3-(苯硫甲基)喹啉，并将其氧化为相应的砜。
Molecules. 2012 May 3;17(5):5081-94. doi: 10.3390/molecules17055081.