The Baylis-Hillman approach to quinoline derivatives.
作者信息
Familoni Oluwole B, Klaas Phindile J, Lobb Kevin A, Pakade Vusumzi E, Kaye Perry T
机构信息
Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa.
出版信息
Org Biomol Chem. 2006 Nov 7;4(21):3960-5. doi: 10.1039/b608592j. Epub 2006 Sep 25.
DOI:10.1039/b608592j
PMID:17047876
Abstract
Baylis-Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo- and regioselectivity of cyclisation appears to be influenced by the choice of both the substrate and the reagent system, and competing reactions have been observed.
摘要
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