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在对甲苯磺酸辅助下，利用高温水和微波加热，通过一锅三组分反应高效直接合成多取代茚并[1,2 - b]喹啉。

Efficient and direct synthesis of poly-substituted indeno[1,2-b]quinolines assisted by p-toluene sulfonic acid using high-temperature water and microwave heating via one-pot, three-component reaction.

作者信息

Tu Shu-Jiang, Jiang Bo, Zhang Jun-Yong, Jia Run-Hong, Zhang Yan, Yao Chang-Sheng

机构信息

Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plants, Xuzhou, Jiangsu, 211116, P R China.

出版信息

Org Biomol Chem. 2006 Nov 7;4(21):3980-5. doi: 10.1039/b611462h. Epub 2006 Sep 29.

DOI:10.1039/b611462h
PMID:17047879
Abstract

Reactions of aldehydes, 1,3-indanedione and enaminones were successfully carried out using p-toluene sulfonic acid (p-TsOH) as a catalyst and high-temperature water as a solvent under microwave irradiation. This method provided several advantages such as rapid reaction times, high yields, and a simple workup procedure. In addition, a possible mechanism to account for the reaction was proposed.

摘要

在微波辐射下，以对甲苯磺酸（p-TsOH）为催化剂、高温水为溶剂，成功实现了醛、1,3-茚二酮和烯胺酮的反应。该方法具有反应时间短、产率高和后处理程序简单等优点。此外，还提出了一种可能的反应机理。

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