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用于可持续药物递送应用的智能TiO纳米管平台的最新进展。

Recent advances on smart TiO nanotube platforms for sustainable drug delivery applications.

作者信息

Wang Qun, Huang Jian-Ying, Li Hua-Qiong, Zhao Allan Zi-Jian, Wang Yi, Zhang Ke-Qin, Sun Hong-Tao, Lai Yue-Kun

机构信息

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou; National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou.

National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou.

出版信息

Int J Nanomedicine. 2016 Dec 20;12:151-165. doi: 10.2147/IJN.S117498. eCollection 2017.

DOI:10.2147/IJN.S117498
PMID:28053530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5191578/
Abstract

To address the limitations of traditional drug delivery, TiO nanotubes (TNTs) are recognized as a promising material for localized drug delivery systems. With regard to the excellent biocompatibility and physicochemical properties, TNTs prepared by a facile electrochemical anodizing process have been used to fabricate new drug-releasing implants for localized drug delivery. This review discusses the development of TNTs applied in localized drug delivery systems, focusing on several approaches to control drug release, including the regulation of the dimensions of TNTs, modification of internal chemical characteristics, adjusting pore openings by biopolymer coatings, and employing polymeric micelles as drug nanocarriers. Furthermore, rational strategies on external conditions-triggered stimuli-responsive drug release for localized drug delivery systems are highlighted. Finally, the review concludes with the recent advances on TNTs for controlled drug delivery and corresponding prospects in the future.

摘要

为了解决传统药物递送的局限性，二氧化钛纳米管（TNTs）被认为是用于局部药物递送系统的一种有前景的材料。鉴于其优异的生物相容性和物理化学性质，通过简便的电化学阳极氧化工艺制备的TNTs已被用于制造用于局部药物递送的新型药物释放植入物。本文综述了应用于局部药物递送系统的TNTs的发展，重点讨论了几种控制药物释放的方法，包括TNTs尺寸的调控、内部化学特性的修饰、通过生物聚合物涂层调节孔口以及使用聚合物胶束作为药物纳米载体。此外，还强调了用于局部药物递送系统的外部条件触发的刺激响应性药物释放的合理策略。最后，本文综述总结了TNTs在药物控释方面的最新进展以及未来相应的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4b9/5191578/0d513daab9e5/ijn-12-151Fig11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4b9/5191578/0d513daab9e5/ijn-12-151Fig11.jpg

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