[大鼠胃肠中黄芩苷和黄芩素吸收动力学研究]
[Studies on the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines].
作者信息
Liu Tai-ming, Jiang Xue-hua
机构信息
West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2006 Jun;31(12):999-1001.
OBJECTIVE
To study the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines.
METHOD
The drug concentration by in situ perfusion in rats were determined by HPLC.
RESULT
The hourly absorption percentages of baicalin in stomach, small intestine and colon were 8.05%, - 0.94% and 2.32%, respectively, and baioalein with 34.53%, 30.61% and 4.89%, respectively. The absorption rate constants of baicalein were 0.090 7, 0.083 7, 0.076 6 and 0.048 3, respectively in duodenum, jejunum, ileum and colon.
CONCLUSION
Baicalin is moderately absorbed in stomach and poorly in small intestine and colon; Baicalein is well absorbed in stomach and small intestine but worse in colon, suggesting that the former is more suitable to be administered orally. The extensive absorption segments of bacailein suggests that it can be processed into a sustained-release preparation.
目的
研究黄芩苷和黄芩素在大鼠胃肠道的吸收动力学。
方法
采用高效液相色谱法测定大鼠原位灌注的药物浓度。
结果
黄芩苷在胃、小肠和结肠的每小时吸收百分率分别为8.05%、 - 0.94%和2.32%，黄芩素分别为34.53%、30.61%和4.89%。黄芩素在十二指肠、空肠、回肠和结肠的吸收速率常数分别为0.090 7、0.083 7、0.076 6和0.048 3。
结论
黄芩苷在胃中吸收适中，在小肠和结肠中吸收较差；黄芩素在胃和小肠中吸收良好，但在结肠中较差，表明前者更适合口服给药。黄芩素的广泛吸收段表明其可制成缓释制剂。
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