Ma Zeng-chun, Gao Yue, Tan Hong-ling, Xiao Cheng-rong, Wu Hong-jin, Wang Sheng-qi
Institute of Radiation Medicine, Beijing, China.
Zhongguo Zhong Yao Za Zhi. 2006 May;31(9):766-9.
To research the effects of fufangdenshen tablets on atherosclerotic plasma protein using proteomic technique and further explore its potential molecular mechanism to cure atherosclerosis.
The plasma of normal, atherosclerosis and cured group were collected, and the albumin in plasma was removed. Proteomic protocol involved of 2-DE, image analysis and spectrometry detection was used to detect regulated plasma protein by fufangdenshen tablets.
3 decreased expressed and 6 higher protein in atherosclerotic plasma could be recovered by fufangdenshen tablets. The levels of fibrinogen, Granzyme C and immunoglobulin were decreased by fufangdenshen tablets.
The levels of fibrinogen, Granzyme C in atherosclerotic plasma could be decreased by fufangdenshen tablets. The effects of fufangdenshen tablets on atherosclerosis included that: inhibition of adhesion of monocyte, inhibition of proliferation and migration of VSMC, and weakening of inflammation.
运用蛋白质组学技术研究复方丹参片对动脉粥样硬化血浆蛋白的影响，并进一步探讨其治疗动脉粥样硬化的潜在分子机制。
收集正常组、动脉粥样硬化组及治疗组的血浆，去除血浆中的白蛋白。采用包括二维电泳、图像分析和光谱检测的蛋白质组学方法，检测复方丹参片对血浆蛋白的调节作用。
复方丹参片可使动脉粥样硬化血浆中3种表达降低的蛋白及6种表达升高的蛋白恢复正常。复方丹参片可降低纤维蛋白原、颗粒酶C和免疫球蛋白的水平。
复方丹参片可降低动脉粥样硬化血浆中纤维蛋白原、颗粒酶C的水平。复方丹参片对动脉粥样硬化的作用包括：抑制单核细胞黏附、抑制血管平滑肌细胞增殖和迁移以及减轻炎症反应。
