Schwenger V, Keller T, Hofmann N, Hoffmann O, Sommerer C, Nahm A M, Morath C, Zeier M, Krumme B
Division of Nephrology, University Medical Hospital, Heidelberg, Germany.
Am J Transplant. 2006 Nov;6(11):2721-4. doi: 10.1111/j.1600-6143.2006.01524.x.
A resistance index (RI) of 0.8 or higher was shown to be a strong predictor of kidney allograft and patient survival. Uncertainties persist since the intrarenal RI is closely associated with the vascular stiffness of the allograft recipient. To clarify the diagnostic value of RI further, we analyzed parameters of vascular stiffness of the recipient and intrarenal RI of the renal allograft. In a prospective study laboratory and clinical parameters, pulse wave velocity (PWV), intima media thickness (IMT) and RI were obtained in 76 kidney allograft patients. We found that the RI values significantly correlated with the PWV (p < 0.05) and the recipients age (p < 0.01) but not with the donor age and renal function. Using multiple regression analysis recipient age, PWV, pulse pressure (PP) and IMT were identified as independent factors influencing RI values. For a more correct interpretation of the RI values in renal allografts parameters of vascular stiffness such as IMT, PP or PWV should be included.
肾移植阻力指数（RI）≥0.8是预测肾移植和患者生存的有力指标。由于肾内RI与移植肾受者血管僵硬度密切相关，因此仍存在不确定性。为进一步明确RI的诊断价值，我们分析了受者血管僵硬度参数和肾移植肾内RI。在一项前瞻性研究中，我们获取了76例肾移植患者的实验室和临床参数，包括脉搏波速度（PWV）、内膜中层厚度（IMT）和RI。我们发现RI值与PWV（p<0.05）和受者年龄（p<0.01）显著相关，但与供者年龄和肾功能无关。多元回归分析显示，受者年龄、PWV、脉压（PP）和IMT是影响RI值的独立因素。为了更准确地解释肾移植中的RI值，应纳入血管僵硬度参数，如IMT、PP或PWV。
