Olsburgh J D, Godbole H C, O'Donnell P J, Koffman G C, Taylor J D, Khan M S
Department of Urology, Guy's & St. Thomas' NHS Foundation Trust & GKT School of Medicine, London SE1 9RT, UK.
Am J Transplant. 2006 Nov;6(11):2809-11. doi: 10.1111/j.1600-6143.2006.01539.x.
Renal transplantation is the best treatment for end-stage renal disease. The discrepancy between donor organ supply and demand continues to widen. Maximum efforts should be made to make use of donor kidneys and we suggest that polycystic kidneys can be suitable marginal donor organs. Five polycystic cadaveric donor kidneys were transplanted in four recipients at our institution between year 2000 and 2004. The donor kidneys were either of normal size or moderately enlarged (less than 15 x 10 cm). Donor ages were 24, 46 and 55 years. All donors had normal serum creatinine at the time of organ retrieval. Recipients gave informed consent to be transplanted with the polycystic kidneys. Three of four recipients had primary graft function. The patient with primary nonfunction required graft nephrectomy 8 weeks post-transplantation. One patient died due to cardiovascular causes with a functioning graft 18 months after transplantation. Two patients remain well, 26 and 58 months after transplantation, with normal graft function. Our experience and the limited evidence from the literature suggest that, with careful selection of both donor and recipient, transplantation of cadaveric polycystic donor kidneys should be considered given the current organ shortage.
肾移植是终末期肾病的最佳治疗方法。供体器官供需之间的差距持续扩大。应尽最大努力利用供肾，我们认为多囊肾可作为合适的边缘供体器官。2000年至2004年期间，我们机构将5个多囊尸体供肾移植给了4名受者。供肾大小正常或中度增大（小于15×10厘米）。供体年龄分别为24岁、46岁和55岁。所有供体在器官获取时血清肌酐均正常。受者均签署知情同意书，接受多囊肾移植。4名受者中有3名移植肾获得原发性功能。原发性无功能的患者在移植后8周需要进行移植肾切除术。1例患者在移植18个月后因心血管原因死亡，移植肾仍有功能。2例患者在移植后26个月和58个月情况良好，移植肾功能正常。我们的经验以及文献中的有限证据表明，鉴于目前器官短缺的情况，在仔细选择供体和受体的情况下，应考虑移植尸体多囊供肾。
