低血糖对人体细胞外环磷酸腺苷水平的影响。

Effect of hypoglycemia on extracellular levels of cyclic AMP in man.

作者信息

Hamet P, Lowder S C, Hardman J G, Liddle G W

出版信息

Metabolism. 1975 Oct;24(10):1139-44. doi: 10.1016/0026-0495(75)90150-x.

Abstract

This study was designed to assess the response of cyclic AMP to "endogenous" hormonal stimulation resulting from insulin-induced hypoglycemia. Insulin was administered to four normal subjects and four adrenalectomized patients. Hypoglycemia resulted in four-fold increases in plasma cyclic AMP. This response is thought to be secondary to beta-adrenergic stimulation for the following reasons: (1) the response was absent in adrenalectomized, cortisol-treated subjects; (2) it was abolished by propranolol; and (3) urinary excretion of cyclic AMP did not reflect the rise in plasma cyclic AMP.

摘要

本研究旨在评估环磷酸腺苷（cAMP）对胰岛素诱导的低血糖所产生的“内源性”激素刺激的反应。对4名正常受试者和4名肾上腺切除患者给予胰岛素。低血糖导致血浆环磷酸腺苷增加了四倍。由于以下原因，这种反应被认为是β-肾上腺素能刺激的继发反应：（1）在肾上腺切除并接受皮质醇治疗的受试者中没有这种反应；（2）它被普萘洛尔消除；（3）环磷酸腺苷的尿排泄量并未反映血浆环磷酸腺苷的升高。