选择性和非选择性β-肾上腺素能受体阻滞剂以及纳洛酮输注对人体胰岛素诱导的低血糖恢复的激素机制的影响。
The effect of selective and non-selective beta-adrenoceptor blockade, and of naloxone infusion, on the hormonal mechanisms of recovery from insulin-induced hypoglycaemia in man.
作者信息
Armitstead J G, Lightman S L, Brown M J, Causon R C, Vaughan N J
出版信息
Br J Clin Pharmacol. 1983 Dec;16(6):718-21. doi: 10.1111/j.1365-2125.1983.tb02248.x.
Abstract
The rise in plasma adenosine-3',5'-monophosphate occurring in response to insulin induced hypoglycaemia in normal human subjects, was abolished by non-selective beta-adrenoceptor blockade but unaffected by selective beta 1-adrenoceptor blockade. This implies that the rise is secondary to beta 2-adrenoceptor stimulation. The abolition of this rise by non-selective beta-adrenoceptor blockade had no pronounced effect on the recovery from hypoglycaemia. Endogenous opiate receptor blockade with naloxone had no significant effect on the recovery from insulin induced hypoglycaemia, or the hormonal mechanisms involved.
摘要
正常人类受试者因胰岛素诱导的低血糖而发生的血浆3',5'-单磷酸腺苷升高，可被非选择性β-肾上腺素能受体阻滞剂消除，但不受选择性β1-肾上腺素能受体阻滞剂影响。这意味着该升高是β2-肾上腺素能受体刺激的继发效应。非选择性β-肾上腺素能受体阻滞剂消除这种升高对低血糖恢复没有明显影响。用纳洛酮进行内源性阿片受体阻滞对胰岛素诱导的低血糖恢复或所涉及的激素机制没有显著影响。
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