Tarlatzis B C, Kolibianakis E M
Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Best Pract Res Clin Obstet Gynaecol. 2007 Feb;21(1):57-65. doi: 10.1016/j.bpobgyn.2006.08.002. Epub 2006 Oct 16.
Gonadotropin-releasing hormone (GnRH) agonists were introduced in ovarian stimulation for in-vitro fertilization to suppress the premature surge of luteinizing hormone (LH). Although agonist use is accompanied by a series of disadvantages, including hypoestrogenaemia, cyst formation, a requirement for a prolonged period of downregulation, and an increase in follicle-stimulating hormone (FSH) and LH as soon as the agonist is administered, agonists became well accepted in clinical practice as their use was also associated with increased rates of pregnancy. However, the recent development of side-effect-free GnRH antagonists, characterized by an immediate mode of action and a shorter period of administration. Provides clinicians with flexibility in terms of administration, and offers patients a friendlier method of ovarian stimulation. Comparative studies between the two analogues have suggested that the use of antagonists is associated with a shorter duration of FSH stimulation and a decreased incidence of hospital admission due to the occurrence of ovarian hyperstimulation syndrome, while the probability of a live birth does not depend on the type of analogue used.
促性腺激素释放激素（GnRH）激动剂被引入体外受精的卵巢刺激过程中，以抑制促黄体生成素（LH）的过早激增。尽管使用激动剂伴随着一系列缺点，包括低雌激素血症、囊肿形成、需要长时间的降调节以及在给予激动剂后促卵泡生成素（FSH）和LH升高，但由于其使用也与妊娠率增加相关，激动剂在临床实践中得到了广泛认可。然而，最近开发出了无副作用的GnRH拮抗剂，其特点是作用方式迅速且给药期较短。这为临床医生在给药方面提供了灵活性，并为患者提供了一种更友好的卵巢刺激方法。两种类似物之间的比较研究表明，使用拮抗剂与FSH刺激持续时间较短以及因卵巢过度刺激综合征入院的发生率降低相关，而活产的概率并不取决于所使用类似物的类型。
