来自里海黄杨的新型生物活性甾体生物碱。

New bioactive steroidal alkaloids from Buxus hyrcana.

作者信息

Babar Zaheer Uddin, Ata Athar, Meshkatalsadat Mohammad Hadi

机构信息

Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9.

出版信息

Steroids. 2006 Dec;71(13-14):1045-51. doi: 10.1016/j.steroids.2006.09.002. Epub 2006 Oct 17.

DOI:10.1016/j.steroids.2006.09.002

PMID:17049575

Abstract

Phytochemical studies on the crude methanolic extract of Buxus hyrcana, collected from Iran, resulted in the isolation of two new steroidal alkaloids, (+)-O6-buxafurandiene (1) and (+)-7-deoxy-O6-buxafurandiene (2) along with four known steroidal bases, (+)-benzoylbuxidienine (3), (+)-buxapapillinine (4), (+)-buxaquamarine (5) and (+)-irehine (6). The structures of these new and known compounds were established with the aid of extensive NMR spectroscopic studies. Compounds 1 and 2 belong to the rarely occurring class of Buxus alkaloids having a tetrahydrofuran ring incorporated in their structures. Compounds 1-6 exhibited acetylcholinesterase enzyme inhibitory activity.

摘要

对采自伊朗的高加索黄杨粗甲醇提取物进行的植物化学研究，分离出两种新的甾体生物碱，(+)-O6-布沙呋喃二烯(1)和(+)-7-脱氧-O6-布沙呋喃二烯(2)，以及四种已知的甾体碱，(+)-苯甲酰布西地宁(3)、(+)-布沙帕皮林宁(4)、(+)-布沙喹马林(5)和(+)-伊雷辛(6)。借助广泛的核磁共振光谱研究确定了这些新化合物和已知化合物的结构。化合物1和2属于结构中含有四氢呋喃环的罕见的黄杨生物碱类别。化合物1 - 6表现出乙酰胆碱酯酶抑制活性。