羽毛形态发生中的分子信号传导。
Molecular signaling in feather morphogenesis.
作者信息
Lin Chih-Min, Jiang Ting Xin, Widelitz Randall B, Chuong Cheng-Ming
机构信息
Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA.
出版信息
Curr Opin Cell Biol. 2006 Dec;18(6):730-41. doi: 10.1016/j.ceb.2006.10.009. Epub 2006 Oct 17.
Abstract
The development and regeneration of feathers have gained much attention recently because of progress in the following areas. First, pattern formation. The exquisite spatial arrangement provides a simple model for decoding the rules of morphogenesis. Second, stem cell biology. In every molting, a few stem cells have to rebuild the entire epithelial organ, providing much to learn on how to regenerate an organ physiologically. Third, evolution and development ('Evo-Devo'). The discovery of feathered dinosaur fossils in China prompted enthusiastic inquiries about the origin and evolution of feathers. Progress has been made in elucidating feather morphogenesis in five successive phases: macro-patterning, micro-patterning, intra-bud morphogenesis, follicle morphogenesis and regenerative cycling.
摘要
由于以下领域取得的进展，羽毛的发育和再生最近备受关注。第一，模式形成。这种精妙的空间排列为解码形态发生规则提供了一个简单模型。第二，干细胞生物学。在每次换羽过程中，少数干细胞必须重建整个上皮器官，这为了解如何在生理上再生一个器官提供了很多研究内容。第三，进化与发育（“Evo-Devo”）。在中国发现的带羽毛恐龙化石引发了人们对羽毛起源和进化的热烈探究。在阐明羽毛形态发生的五个连续阶段方面取得了进展：宏观模式形成、微观模式形成、芽内形态发生、毛囊形态发生和再生循环。
相似文献
1
Molecular signaling in feather morphogenesis.羽毛形态发生中的分子信号传导。
Curr Opin Cell Biol. 2006 Dec;18(6):730-41. doi: 10.1016/j.ceb.2006.10.009. Epub 2006 Oct 17.
2
In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages.追寻金羊毛：通过研究皮肤附属物的综合生物学来揭示形态发生的原理。
Integr Biol (Camb). 2011 Apr;3(4):388-407. doi: 10.1039/c0ib00108b. Epub 2011 Mar 24.
3
Development, regeneration, and evolution of feathers.羽毛的发育、再生和演化。
Annu Rev Anim Biosci. 2015;3:169-95. doi: 10.1146/annurev-animal-022513-114127. Epub 2014 Nov 3.
4
Molecular biology of feather morphogenesis: a testable model for evo-devo research.羽毛形态发生的分子生物学：一个用于演化发育生物学研究的可检验模型。
J Exp Zool B Mol Dev Evol. 2003 Aug 15;298(1):109-22. doi: 10.1002/jez.b.29.
5
Avian skin development and the evolutionary origin of feathers.鸟类皮肤发育与羽毛的进化起源。
J Exp Zool B Mol Dev Evol. 2003 Aug 15;298(1):57-72. doi: 10.1002/jez.b.26.
6
Exploration of key regulators driving primary feather follicle induction in goose skin.探索鹅皮肤初级羽滤泡诱导的关键调节因子。
Gene. 2020 Mar 20;731:144338. doi: 10.1016/j.gene.2020.144338. Epub 2020 Jan 7.
7
Evolutionary origin of the feather epidermis.羽毛表皮的进化起源。
Dev Dyn. 2005 Feb;232(2):256-67. doi: 10.1002/dvdy.20291.
8
Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion.多个调控模块是鳞片到羽毛转化所必需的。
Mol Biol Evol. 2018 Feb 1;35(2):417-430. doi: 10.1093/molbev/msx295.
9
Feather arrays are patterned by interacting signalling and cell density waves.羽列是通过相互作用的信号和细胞密度波来形成模式的。
PLoS Biol. 2019 Feb 21;17(2):e3000132. doi: 10.1371/journal.pbio.3000132. eCollection 2019 Feb.
10
beta-catenin signaling can initiate feather bud development.β-连环蛋白信号传导可启动羽芽发育。
Development. 1999 Aug;126(16):3509-21. doi: 10.1242/dev.126.16.3509.
引用本文的文献
1
Hemp Seed-Derived Exosomes Protect Against Dihydrotestosterone-Induced Chicken Feather Growth Inhibition.大麻籽衍生的外泌体可预防二氢睾酮诱导的鸡羽毛生长抑制。
Pharmaceuticals (Basel). 2025 Aug 13;18(8):1192. doi: 10.3390/ph18081192.
2
Comparative transcriptomic analysis reveals breed-specific developmental characters of skin and feather follicles between Anser Cygnoides and Anser Anser.比较转录组分析揭示了鸿雁和灰雁之间皮肤和毛囊的品种特异性发育特征。
Poult Sci. 2025 Jun 28;104(10):105457. doi: 10.1016/j.psj.2025.105457.
3
Exacerbated sonic hedgehog signalling promotes a transition from chemical pre-patterning of chicken reticulate scales to mechanical skin folding.Sonic hedgehog信号增强促进了鸡网状鳞片从化学预模式到机械性皮肤折叠的转变。
Open Biol. 2025 Apr;15(4):240342. doi: 10.1098/rsob.240342. Epub 2025 Apr 16.
4
Modification of Keratin Integrations and the Associated Morphogenesis in Frizzling Chicken Feathers.卷毛鸡羽毛中角蛋白整合的改变及相关形态发生
Biology (Basel). 2024 Jun 23;13(7):464. doi: 10.3390/biology13070464.
5
Autofluorescence microscopy as a non-invasive probe to characterize the complex mechanical properties of keratin-based integumentary organs: A feather paradigm.自体荧光显微镜作为一种非侵入性探针用于表征基于角蛋白的皮肤器官的复杂力学特性：以羽毛为例
Chin J Phys. 2023 Dec;86:561-571. doi: 10.1016/j.cjph.2023.10.017. Epub 2023 Oct 13.
6
Transcriptional Characteristics Showed That miR-144-y/FOXO3 Participates in Embryonic Skin and Feather Follicle Development in Zhedong White Goose.转录特征表明，miR-144-y/FOXO3参与浙东白鹅胚胎皮肤和毛囊发育。
Animals (Basel). 2022 Aug 17;12(16):2099. doi: 10.3390/ani12162099.
7
Molecular Signaling and Nutritional Regulation in the Context of Poultry Feather Growth and Regeneration.家禽羽毛生长与再生背景下的分子信号传导与营养调控
Front Physiol. 2020 Jan 21;10:1609. doi: 10.3389/fphys.2019.01609. eCollection 2019.
8
Characterization of Embryonic Skin Transcriptome in at Three Feather Follicles Developmental Stages. characterization of embryonic skin transcriptome in at three feather follicles developmental stages.
G3 (Bethesda). 2020 Feb 6;10(2):443-454. doi: 10.1534/g3.119.400875.
9
Role of the boundary in feather bud formation on one-dimensional bioengineered skin.边界在一维生物工程皮肤羽毛芽形成中的作用。
APL Bioeng. 2018 Feb 13;2(1):016107. doi: 10.1063/1.4989414. eCollection 2018 Mar.
10
Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck.动态转录组谱分析，旨在深入了解家鸭不同羽毛的形态发生和发育。
BMC Genomics. 2018 May 24;19(1):391. doi: 10.1186/s12864-018-4778-7.
本文引用的文献
1
Formation of cutaneous appendages in dermo-epidermal recombinations between reptiles, birds and mammals.爬行动物、鸟类和哺乳动物的真皮-表皮重组中皮肤附属器的形成。
Wilehm Roux Arch Dev Biol. 1975 Dec;177(4):323-340. doi: 10.1007/BF00848183.
2
Distinct mechanisms underlie pattern formation in the skin and skin appendages.不同的机制构成了皮肤和皮肤附属器的模式形成基础。
Birth Defects Res C Embryo Today. 2006 Sep;78(3):280-91. doi: 10.1002/bdrc.20075.
3
Cell structure of barb ridges in down feathers and juvenile wing feathers of the developing chick embryo: barb ridge modification in relation to feather evolution.发育中的鸡胚绒羽和幼雏翅羽羽枝嵴的细胞结构：与羽毛进化相关的羽枝嵴修饰
Ann Anat. 2006 Jul;188(4):303-18. doi: 10.1016/j.aanat.2006.01.011.
4
Cell structure of developing downfeathers in the zebrafinch with emphasis on barb ridge morphogenesis.斑胸草雀发育中绒羽的细胞结构，重点关注羽枝嵴的形态发生。
J Anat. 2006 May;208(5):621-42. doi: 10.1111/j.1469-7580.2006.00580.x.
5
Fine structure of juvenile feathers of the zebrafinch in relation to the evolution and diversification of pennaceous feathers.斑胸草雀幼羽的精细结构与正羽的进化和多样化的关系
J Submicrosc Cytol Pathol. 2005 Nov;37(3-4):323-43.
6
Engineering stem cells into organs: topobiological transformations demonstrated by beak, feather, and other ectodermal organ morphogenesis.将干细胞工程化为器官：通过喙、羽毛及其他外胚层器官形态发生所展示的拓扑生物学转变。
Curr Top Dev Biol. 2006;72:237-74. doi: 10.1016/S0070-2153(05)72005-6.
7
Before programs: the physical origination of multicellular forms.程序之前：多细胞形式的物理起源。
Int J Dev Biol. 2006;50(2-3):289-99. doi: 10.1387/ijdb.052049sn.
8
Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia.Wnt3a梯度通过上皮细胞的拓扑排列将径向羽毛对称性转变为双侧羽毛对称性。
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):951-5. doi: 10.1073/pnas.0506894103. Epub 2006 Jan 17.
9
Mapping stem cell activities in the feather follicle.绘制毛囊中的干细胞活动图谱。
Nature. 2005 Dec 15;438(7070):1026-9. doi: 10.1038/nature04222.
10
Chicken genome: current status and future opportunities.鸡基因组：现状与未来机遇
Genome Res. 2005 Dec;15(12):1692-8. doi: 10.1101/gr.4141805.
Zotero 插件