Zhu Qing, Tremblay Matthew S
Institute of Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang Province 310014, PR China.
Bioorg Med Chem Lett. 2006 Dec 15;16(24):6170-2. doi: 10.1016/j.bmcl.2006.09.087. Epub 2006 Oct 1.
Iodotrimethylsilane (TMSI), routinely used for the dealkylation of ethers and esters, has been found to efficiently convert allyl and benzyl phosphotriesters into the corresponding iodides under mild, Brønsted-neutral conditions. In contrast, alkyl and aryl phosphotriesters were dealkylated to the corresponding phosphates under identical conditions.
三甲基碘硅烷（TMSI）常用于醚和酯的脱烷基反应，现已发现它能在温和的布朗斯特中性条件下，有效地将烯丙基和苄基磷酸三酯转化为相应的碘化物。相比之下，在相同条件下，烷基和芳基磷酸三酯会脱烷基生成相应的磷酸盐。
