原位生成Mes2Mg作为一种非亲核性碳中心碱试剂，用于将酮高效一锅法转化为硅基烯醇醚。
In situ generation of Mes2Mg as a non-nucleophilic carbon-centred base reagent for the efficient one-pot conversion of ketones to silyl enol ethers.
作者信息
Kerr William J, Watson Allan J B, Hayes Douglas
机构信息
Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, UK G1 1XL.
出版信息
Org Biomol Chem. 2008 Apr 7;6(7):1238-43. doi: 10.1039/b802082e. Epub 2008 Feb 25.
DOI:10.1039/b802082e
PMID:18362964
Abstract
Treatment of commercially available MesMgBr with 1,4-dioxane produces the key Mes(2)Mg reagent in situ which then mediates the deprotonation of ketones to deliver trimethylsilyl enol ethers, at readily accessible temperatures and without any nucleophilic addition, in an expedient and high yielding one-pot process.
摘要
用1,4 - 二氧六环处理市售的MesMgBr原位生成关键试剂Mes(2)Mg，然后在易于达到的温度下，无需任何亲核加成，通过便捷且高产率的一锅法介导酮的去质子化反应以生成三甲基硅基烯醇醚。
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