曲酸及其锰和锌配合物作为潜在的辐射防护剂。
Kojic acid and its manganese and zinc complexes as potential radioprotective agents.
作者信息
Emami Saeed, Hosseinimehr Seyed Jalal, Taghdisi Seyed Mohammad, Akhlaghpoor Shahram
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Bioorg Med Chem Lett. 2007 Jan 1;17(1):45-8. doi: 10.1016/j.bmcl.2006.09.097. Epub 2006 Oct 4.
The naturally occurring fungal metabolite kojic acid and its manganese and zinc complexes have been evaluated as potential radioprotectors in mice. Their toxicity and radioprotective activity (survival rate) have been determined and compared with that of WR-2721 (amifostine). The results of in vivo radioprotection showed that these compounds exhibited significant radioprotective effects against lethal dose of gamma-irradiation in mice.
天然存在的真菌代谢产物曲酸及其锰和锌络合物已被评估为小鼠潜在的辐射防护剂。已测定了它们的毒性和辐射防护活性（存活率），并与WR-2721（氨磷汀）进行了比较。体内辐射防护结果表明，这些化合物对小鼠致死剂量的γ射线照射具有显著的辐射防护作用。
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