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AAGTGA和GAAAGT的多聚化产生了通过模拟干扰素启动子元件来介导病毒诱导性的序列。

Multimerization of AAGTGA and GAAAGT generates sequences that mediate virus inducibility by mimicking an interferon promoter element.

作者信息

Näf D, Hardin S E, Weissmann C

机构信息

Institut für Molekularbiologie I. Universität Zürich, Switzerland.

出版信息

Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1369-73. doi: 10.1073/pnas.88.4.1369.

DOI:10.1073/pnas.88.4.1369
PMID:1705037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC51019/
Abstract

Multimeric AAGTGA and GAAAGT, when inserted before a minimal promoter, mediate virus-inducible transcription. We have determined that the active sequence within these multimers is TGAAAGTGAAAGT, which is structurally similar to GAGAAGTGAAAGT, a positive response element delineated in the beta-interferon gene promoter. Both sequences behave like protoenhancers and are similar as regards induction by virus or interferon regulatory factor 1 when supported by a simian virus 40 enhancer.

摘要

多聚体AAGTGA和GAAAGT插入到最小启动子之前时，可介导病毒诱导的转录。我们已经确定，这些多聚体内的活性序列是TGAAAGTGAAAGT，其结构与β-干扰素基因启动子中描绘的阳性反应元件GAGAAGTGAAAGT相似。当由猿猴病毒40增强子支持时，这两个序列都表现得像原增强子，并且在病毒或干扰素调节因子1诱导方面相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420a/51019/27767d4ff2b3/pnas01054-0296-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420a/51019/11fe818592af/pnas01054-0295-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420a/51019/27767d4ff2b3/pnas01054-0296-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420a/51019/11fe818592af/pnas01054-0295-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420a/51019/27767d4ff2b3/pnas01054-0296-a.jpg

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