不同的途径介导人IFN-α1和IFN-β基因的病毒诱导性。
Different pathways mediate virus inducibility of the human IFN-alpha 1 and IFN-beta genes.
作者信息
MacDonald N J, Kuhl D, Maguire D, Näf D, Gallant P, Goswamy A, Hug H, Büeler H, Chaturvedi M, de la Fuente J, Ruffner H, Meyer F, Weissman C
机构信息
Institut für Molekularbiologie I, Universität Zürich, Switzerland.
出版信息
Cell. 1990 Mar 9;60(5):767-79. doi: 10.1016/0092-8674(90)90091-r.
Multimerization of GAAANN generates sequences frequent in virus-inducible promoters. We distinguished different types of (GAAANN)4 sequences mediating virus inducibility. Type I (NN = GT, GC, CT, or CC) responds to IFNs and to IRF-1 and causes silencing. Type II (NN = TG) and type III (NN = CG) neither silence nor respond to IRF-1 or IFN. Type III mediates constitutive transcription and binds the constitutive IEFga factor, whereas type II binds the novel "TG protein". IFN-beta and IFN-alpha 1 promoters contain different response elements: The former has a type I-like sequence (PRDI) and an NF-kappa B-binding sequence (PRDII); the latter has a type II-like "TG sequence" and possibly additional elements but does not bind NF-kappa B. Type I, type II, and NF-kappa B elements represent three distinct terminal pathways mediating virus induction.
GAAANN的多聚化产生了在病毒诱导型启动子中常见的序列。我们区分了介导病毒诱导性的不同类型的(GAAANN)4序列。I型(NN = GT、GC、CT或CC)对干扰素和IRF-1有反应并导致沉默。II型(NN = TG)和III型(NN = CG)既不沉默也不对IRF-1或干扰素产生反应。III型介导组成型转录并结合组成型IEFga因子，而II型结合新型“TG蛋白”。干扰素-β和干扰素-α1启动子含有不同的反应元件：前者有一个I型样序列(PRDI)和一个NF-κB结合序列(PRDII)；后者有一个II型样“TG序列”以及可能的其他元件，但不结合NF-κB。I型、II型和NF-κB元件代表了介导病毒诱导的三种不同的终末途径。
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