Antmen B, Haytac M C, Sasmaz I, Dogan M C, Ergin M, Tanyeli A
Cukurova University, Faculty of Medicine, Department of Pediatric Hematology/Oncology, Adana, Turkey.
J Periodontol. 2003 Oct;74(10):1514-9. doi: 10.1902/jop.2003.74.10.1514.
Granulocytic sarcoma (GS) is an uncommon extramedullary tumor composed of dense aggregates of immature myeloid precursor cells, which is usually associated with acute or chronic myeloid leukemia. The tumor may also be a predecessor to acute myeloid leukemia (AML). It may be found in any location throughout the body; however, intraoral occurrence is extremely rare. This report describes a case of gingival granulocytic sarcoma that developed prior to AML in a 12-year-old female.
The patient, who had a 3-month history of gingival enlargement, was diagnosed as having granulocytic sarcoma based on clinical, radiological, and histological findings. Although the tumor regressed significantly after two induction chemotherapy courses, the patient subsequently died due to pneumococcal sepsis and pleurisy.
This case report affirms the importance of granulocytic sarcoma in the differential diagnosis of gingival enlargements, since the tumor may occur before bone marrow involvement by leukemic cells.
粒细胞肉瘤（GS）是一种罕见的髓外肿瘤，由未成熟髓系前体细胞密集聚集而成，通常与急性或慢性髓系白血病相关。该肿瘤也可能是急性髓系白血病（AML）的前驱病变。它可出现在全身任何部位；然而，口腔内发生极为罕见。本报告描述了一名12岁女性在发生AML之前出现牙龈粒细胞肉瘤的病例。
该患者有3个月牙龈肿大病史，根据临床、影像学和组织学检查结果被诊断为粒细胞肉瘤。尽管经过两个疗程的诱导化疗后肿瘤明显消退，但患者随后因肺炎球菌败血症和胸膜炎死亡。
本病例报告证实了粒细胞肉瘤在牙龈肿大鉴别诊断中的重要性，因为该肿瘤可能在白血病细胞累及骨髓之前发生。
