Shibayama Y, Yahara M, Nakata K
Department of Pathology, Osaka Medical College, Japan.
J Pathol. 1990 Dec;162(4):335-40. doi: 10.1002/path.1711620411.
This study was undertaken in rats to clarify the mechanisms and time necessary for recovery from vacuolation in liver cells. Vacuoles were produced by congestion of the liver due to constriction of the inferior vena cava just below the diaphragm, and changes in vacuoles were examined quantitatively and qualitatively until 24 h after release of the constriction. Vacuoles in liver cells decreased in number by half within 5 min after recovery from congestion. The remaining vacuoles metamorphosed to hyaline globules by condensation of the contents. The number of hyaline globules increased with a peak occurring at 3-6 h after recovery from congestion, although the number of vacuoles decreased gradually. Only a few small vacuoles and hyaline globules were found in liver cells in pericentral areas at 24 h after recovery from congestion. These data indicate that vacuoles may be discharged promptly from the liver cell cytoplasm after recovery from congestion, and the remaining vacuoles may metamorphose to hyaline globules by condensation of the contents and finally fade into the cytoplasm.
本研究在大鼠身上进行，以阐明肝细胞空泡化恢复的机制及所需时间。通过在膈下紧邻处结扎下腔静脉导致肝脏充血来产生空泡，并在解除结扎后24小时内对空泡变化进行定量和定性检测。肝脏充血恢复后5分钟内，肝细胞内的空泡数量减少一半。剩余的空泡通过内容物浓缩转变为透明小球。尽管空泡数量逐渐减少，但透明小球数量增加，在充血恢复后3 - 6小时达到峰值。充血恢复后24小时，在中央静脉周围区域的肝细胞中仅发现少量小空泡和透明小球。这些数据表明，充血恢复后空泡可能迅速从肝细胞胞质中排出，剩余的空泡可能通过内容物浓缩转变为透明小球，最终融入细胞质中。
