Pettoello-Mantovani M, Casadevall A, Kollmann T R, Rubinstein A, Goldstein H
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461.
Lancet. 1992 Jan 4;339(8784):21-3. doi: 10.1016/0140-6736(92)90142-p.
Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptococcal capsular polysaccharide may enhance HIV-1 infection. In an in-vitro study, the presence of cryptococcal polysaccharide significantly increased (p less than 0.05) production of p24 antigen after infection of H9 cells with HIV-1-infected H9 cells. We also found similar results when lymphocytes from an HIV-1-infected patient were co-cultured with mononuclear cells from an uninfected individual. Our findings suggest a new pathogenic role for the capsular polysaccharide--namely, the capacity to enhance HIV-1 infectivity.
感染新型隐球菌的艾滋病患者预后较差。我们推测隐球菌荚膜多糖的存在可能会增强HIV-1感染。在一项体外研究中，隐球菌多糖的存在显著增加（p小于0.05）了用HIV-1感染H9细胞后H9细胞p24抗原的产生。当将一名HIV-1感染患者的淋巴细胞与一名未感染个体的单核细胞共培养时，我们也发现了类似结果。我们的研究结果提示了荚膜多糖的一种新致病作用，即增强HIV-1感染性的能力。
