Cliffer K D, Burstein R, Giesler G J
Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis 55455.
J Neurosci. 1991 Mar;11(3):852-68. doi: 10.1523/JNEUROSCI.11-03-00852.1991.
Fibers projecting from several levels of the spinal cord to the diencephalon and telencephalon were labeled anterogradely with Phaseolus vulgaris leucoagglutinin injected iontophoretically. Labeled fibers in the thalamus confirmed projections previously observed. In addition, many labeled fibers were seen in the hypothalamus and in telencephalic areas not generally recognized previously as receiving such projections. In the hypothalamus, these areas included the lateral hypothalamus (including the medial forebrain bundle), the posterior hypothalamic area, the dorsal hypothalamic area, the dorsomedial nucleus, the paraventricular nucleus, the periventricular area, the suprachiasmatic nucleus, and the lateral and medial preoptic areas. In the telencephalon, areas with labeled fibers included the ventral pallidum, the globus pallidus, the substantia innominata, the basal nucleus of Meynert, the amygdala (central nucleus), the horizontal and vertical limbs of the diagonal band of Broca, the medial and lateral septal nuclei, the bed nucleus of the stria terminalis, the nucleus accumbens, infralimbic cortex, and medial orbital cortex. These results suggest that somatosensory, possibly including visceral sensory, information is carried directly from the spinal cord to areas in the brain involved in autonomic regulation, motivation, emotion, attention, arousal, learning, memory, and sensory-motor integration. Many of these areas are associated with the limbic system.
通过离子电渗法注射菜豆白细胞凝集素，对从脊髓不同节段投射到间脑和端脑的纤维进行了顺行标记。丘脑内的标记纤维证实了先前观察到的投射。此外，在下丘脑以及以前一般未被认为接受此类投射的端脑区域中也发现了许多标记纤维。在下丘脑中，这些区域包括外侧下丘脑（包括内侧前脑束）、下丘脑后区、下丘脑背侧区、背内侧核、室旁核、室周区、视交叉上核以及视前外侧区和视前内侧区。在端脑中，有标记纤维的区域包括腹侧苍白球、苍白球、无名质、迈内特基底核、杏仁核（中央核）、布罗卡斜角带的水平支和垂直支、内侧和外侧隔核、终纹床核、伏隔核、边缘下皮质和内侧眶额皮质。这些结果表明，躯体感觉信息，可能还包括内脏感觉信息，直接从脊髓传递到大脑中参与自主调节、动机、情绪、注意力、觉醒、学习、记忆和感觉运动整合的区域。其中许多区域与边缘系统相关。
