Datsko B Y, Gafiychuk V V, Lubashevsky I A, Priezzhev A V
Institute for Applied Problems in Mechanics and Mathematics, National Academy of Sciences of Ukraine, Naukova Street 3b, 79053, Lviv, Ukraine.
J Med Eng Technol. 2006 Nov-Dec;30(6):390-6. doi: 10.1080/03091900500467340.
We analyse necrosis growth due to thermal coagulation induced by laser light absorption and limited by heat diffusion into the surrounding live tissue. The tissue is assumed to contain a tumour in the undamaged tissue where the blood perfusion rate does not change during the action. By contrast, normal tissue responds strongly to an increase in the tissue temperature and the blood perfusion rate can grow by tenfold. We study in detail necrosis formation under conditions typical of a real course of thermal therapy treatment. The duration of the treatment is about 5 minutes when a necrosis domain of about 1 cm or above is formed. In particular, if the tumour size is sufficiently large, i.e. it exceeds 1 cm, and the tissue response is not too delayed, i.e. the delay time does not exceed 1 min, then there are conditions under which the relative volume of the damaged normal tissue is small in comparison with the tumour volume after the tumour is totally coagulated.
我们分析了由于激光吸收引起的热凝固导致的坏死生长情况，且这种坏死生长受热量扩散到周围活组织的限制。假设组织中未受损部分含有肿瘤，在激光作用期间，肿瘤部位的血液灌注率不变。相比之下，正常组织对组织温度升高反应强烈，血液灌注率可增长至原来的十倍。我们详细研究了在热疗实际过程典型条件下的坏死形成情况。当形成约1厘米或更大的坏死区域时，治疗持续时间约为5分钟。特别地，如果肿瘤尺寸足够大，即超过1厘米，并且组织反应不太延迟，即延迟时间不超过1分钟，那么在肿瘤完全凝固后，存在受损正常组织的相对体积与肿瘤体积相比很小的情况。
