Shanghai Jiao Tong University, Shanghai 200030, China.
IEEE Trans Nanobioscience. 2009 Sep;8(3):271-80. doi: 10.1109/TNB.2009.2028885.
Gold-nanoparticle-based hyperthermia has attracted considerable attention in the recent ten years in cancer treatment. In hyperthermia-based cancer treatment, in order to produce efficient thermal therapy yet without excessive heat damage to human body, besides the steady-state thermal condition, the transient thermal response is of vital importance. As part of theoretical research associated with nanoparticle-mediated hyperthermia therapy for cancer treatment, the transient heat transfer process of laser interacting with gold nanoparticle in tissue-like medium is investigated. Within the framework of dual-phase-lag (DPL) model, this paper focuses on the microscopic heat transfer performance of a gold nanoparticle in a surrounding medium. A semianalytical solution of 1-D nonhomogenous DPL equation in spherical coordinates is presented for a heat transfer process with a constant laser heat source and a short-pulsed laser heating source. Results show that the transient temperature calculated by DPL model greatly exceeds that predicted by the classical diffusion model, with either a constant source or a pulsed source. This phenomenon is mainly attributed by the phase lag of heat flux in the surrounding tissue.
基于金纳米颗粒的热疗在近十年中引起了人们的广泛关注，在基于热疗的癌症治疗中，为了产生有效的热疗效果，而又不会对人体造成过度的热损伤，除了稳态热状态外，瞬态热响应至关重要。作为与纳米颗粒介导的癌症热疗治疗相关的理论研究的一部分，研究了激光与组织样介质中的金纳米颗粒相互作用的瞬态传热过程。在双时滞（DPL）模型的框架内，本文重点研究了周围介质中一个金纳米颗粒的微观传热性能。针对具有恒定激光热源和短脉冲激光加热源的传热过程，给出了球坐标系中 1-D 非齐次 DPL 方程的半解析解。结果表明，无论是恒定源还是脉冲源，DPL 模型计算的瞬态温度都大大超过了经典扩散模型的预测值。这种现象主要归因于周围组织中热流的相位滞后。
