Hawkins R G, Burgess E D, Watanabe M
Department of Medicine, Faculty of Medicine, University of Calgary, Alberta, Canada.
J Cardiovasc Pharmacol. 1990;16 Suppl 8:S62-4.
Disturbed phosphate (PO4) metabolism has been documented in spontaneously hypertensive rats but poorly studied in humans. Twenty-seven drug-free hypertensive subjects were studied on both a 10- and 100-mmol sodium diet. The response of mean arterial pressure to sodium repletion was directly correlated to the response of plasma renin activity (r = 0.540, p = 0.004) and inversely related to the percent response of serum PO4 concentrations. In the sodium-replete state serum PO4 concentration correlated inversely with plasma vitamin D concentration (r = 0.419, p = 0.026), consistent with PO4 acting as a determinate of vitamin D production. The response of serum calcium and plasma vitamin D concentrations to sodium repletion were correlated (r = 0.392, p = 0.043), consistent with serum calcium levels being a dependent variable, but the responses of serum PO4 and vitamin D concentrations were not. This study suggests that PO4 metabolism may be a determinate of blood pressure response to sodium repletion.
自发性高血压大鼠存在磷酸盐（PO4）代谢紊乱，但在人类中的相关研究较少。对27名未服用药物的高血压受试者进行了10 mmol和100 mmol钠饮食的研究。平均动脉压对钠补充的反应与血浆肾素活性的反应直接相关（r = 0.540，p = 0.004），与血清PO4浓度的百分比反应呈负相关。在钠充足状态下，血清PO4浓度与血浆维生素D浓度呈负相关（r = 0.419，p = 0.026），这与PO4作为维生素D生成的决定因素一致。血清钙和血浆维生素D浓度对钠补充的反应具有相关性（r = 0.392，p = 0.043），这与血清钙水平作为一个因变量一致，但血清PO4和维生素D浓度的反应不相关。这项研究表明，PO4代谢可能是血压对钠补充反应的一个决定因素。
