Galeone C, Negri E, Pelucchi C, La Vecchia C, Bosetti C, Hu J
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Ann Oncol. 2007 Feb;18(2):388-92. doi: 10.1093/annonc/mdl387. Epub 2006 Oct 23.
We studied the relationship between dietary intake of vegetables and fruit and lung cancer risk in Harbin, Heilongjiang province, northeast China, an area with a very high baseline risk of lung cancer in both sexes.
We used data from a case-control study, conducted from 1987 to 1990, among 218 cases with incident, histologically confirmed lung cancer and 436 controls admitted to the same hospitals as cases with non-neoplastic, non-lung diseases unrelated to smoking and other potential risk factors for lung cancer.
Compared with the lowest tertile of intake of vegetables, fruit or both, the multivariate odds ratios (ORs) for the highest tertile of intake were 0.39 [95% confidence interval (CI) 0.25-0.62], 0.73 (95% CI 0.48-1.11) and 0.40 (95% CI 0.25-0.63), respectively. In particular, high intake of Chinese cabbage (OR = 0.53), chives (OR = 0 .54), carrots (OR = 0.51) and celery (OR = 0.40) was inversely associated with lung cancer. The OR was more than six-fold elevated for smokers reporting low intake of vegetables, and more than four-fold elevated for smokers reporting low intake of fruit, as compared with never smokers reporting high intake of these items.
In agreement with previous studies, we found an inverse relation between vegetable and fruit intake and lung cancer risk in both strata of current and never smokers.
我们在中国东北黑龙江省哈尔滨市研究了蔬菜和水果的膳食摄入量与肺癌风险之间的关系，该地区男女肺癌基线风险都非常高。
我们使用了一项病例对照研究的数据，该研究于1987年至1990年进行，纳入了218例新发病例、经组织学确诊的肺癌患者以及436名对照，这些对照与病例来自同一家医院，患有与吸烟及其他潜在肺癌风险因素无关的非肿瘤性非肺部疾病。
与蔬菜、水果或两者摄入量最低的三分位数相比，摄入量最高的三分位数的多因素比值比（OR）分别为0.39[95%置信区间（CI）0.25 - 0.62]、0.73（95%CI 0.48 - 1.11）和0.40（95%CI 0.25 - 0.63）。特别是，大白菜（OR = 0.53）、韭菜（OR = 0.54）、胡萝卜（OR = 0.51）和芹菜（OR = 0.40）的高摄入量与肺癌呈负相关。与报告高摄入量的从不吸烟者相比，报告低蔬菜摄入量的吸烟者的OR升高了六倍多，报告低水果摄入量的吸烟者的OR升高了四倍多。
与先前的研究一致，我们发现无论是当前吸烟者还是从不吸烟者，蔬菜和水果摄入量与肺癌风险之间均呈负相关。
