Khawaja Owais, Petrone Andrew B, Aleem Sohaib, Manzoor Kamran, Gaziano John M, Djousse Luc
Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, USA.
Divisions of Aging, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.
Zhongguo Fei Ai Za Zhi. 2014 Sep 20;17(9):649-55. doi: 10.3779/j.issn.1009-3419.2014.09.02.
Lung cancer is the most common cancer and cancer related cause of death worldwide. However, the association between sleep duration and incident lung cancer has not been investigated in a prospective cohort study.
We prospectively examined the association between sleep duration and incident lung cancer in a cohort of 21,026 United States (US) male physicians. Self-reported sleep duration was ascertained during 2002 annual follow-up questionnaire. Incident lung cancer was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risk of incident lung cancer.
The average age at baseline was 68.3±8.8 yr. During a mean follow up of 7.5 (±2.2) yr, 150 cases of lung cancer occurred. Using 7 h of sleep as the reference group, multivariable adjusted hazard ratios (95%CI) for lung cancer were 1.18 (0.77-1.82), 1.0 (ref), and 0.97 (0.67-1.41) from lowest to the highest category of sleep duration (P for quadratic trend 0.697), respectively. In a secondary analysis, smoking status did not modify the sleep duration-lung cancer association (P=0.78). There was no evidence for an interaction between sleep duration and sleep apnea on the risk of lung cancer either (P=0.65).
Our data failed to show a higher risk of lung cancer in association with altered sleep duration among US male physicians.
肺癌是全球最常见的癌症及与癌症相关的死亡原因。然而，睡眠时长与肺癌发病之间的关联尚未在前瞻性队列研究中得到探究。
我们前瞻性地研究了21026名美国男性医生队列中睡眠时长与肺癌发病之间的关联。通过2002年年度随访问卷确定自我报告的睡眠时长。通过年度随访问卷确定肺癌发病情况。采用Cox回归估计肺癌发病的相对风险。
基线时的平均年龄为68.3±8.8岁。在平均7.5（±2.2）年的随访期间，发生了150例肺癌病例。以7小时睡眠作为参照组，睡眠时长从最低到最高类别，肺癌的多变量调整风险比（95%CI）分别为1.18（0.77 - 1.82）、1.0（参照）和0.97（0.67 - 1.41）（二次趋势P值为0.697）。在一项二次分析中，吸烟状况并未改变睡眠时长与肺癌之间的关联（P = 0.78）。也没有证据表明睡眠时长与睡眠呼吸暂停在肺癌风险上存在相互作用（P = 0.65）。
我们的数据未能显示美国男性医生中睡眠时长改变与肺癌风险升高有关。
