Knight Vernon, Koshkina N V, Golunski E, Roberts L E, Gilbert B E
Trans Am Clin Climatol Assoc. 2004;115:395-404; discussion 404.
Paclitaxel (PTX) is a lipophilic agent with broad anticancer activity. In the present study we examined the antitumor effect and toxicity of co-administration of cyclosporine A (CsA) and PTX in liposomal aerosol using the Renca lung metastases mouse model. The untreated and PTX-only groups exhibited cancer growth while CsA aerosol plus PTX had more favorable effects on tumor growth. Weight loss was seen in mice treated with CsA/PTX+CsA by day 9 to 22. Histopathological examination showed no toxicity following treatment. The findings offer evidence that a combination of CsA and PTX may be suitable for aerosol treatment of lung cancer if it is possible to control toxicity of the therapy.
紫杉醇（PTX）是一种具有广泛抗癌活性的亲脂性药物。在本研究中，我们使用Renca肺转移小鼠模型，研究了环孢素A（CsA）与PTX脂质体气雾剂联合给药的抗肿瘤作用和毒性。未治疗组和仅使用PTX组的肿瘤生长，而CsA气雾剂加PTX对肿瘤生长有更有利的影响。到第9至22天，接受CsA/PTX+CsA治疗的小鼠出现体重减轻。组织病理学检查显示治疗后无毒性。这些发现提供了证据，表明如果能够控制该疗法的毒性，CsA和PTX联合使用可能适用于肺癌的气雾剂治疗。
