Yamaguchi S, Knight R T
Department of Neurology, University of California, Davis, Veterans Administration Medical Center, Martinez 94553.
Electroencephalogr Clin Neurophysiol. 1991 Apr;78(4):297-301. doi: 10.1016/0013-4694(91)90184-6.
Event-related brain potentials (ERPs) to somatosensory task-relevant targets and task-irrelevant novel (tactile and shock) stimuli were studied in 30 subjects between the ages of 18 and 79. Target and novel P300 latencies increased linearly with age at comparable rates. P300 amplitudes and scalp topographies also changed with age. P300 amplitudes remained constant at frontal sites and decreased at central and parietal sites for both target and novel stimuli with increasing age. The current results extend the age-related novel P300 changes reported in the auditory and visual modalities to the somatosensory system. The age-related amplitude reduction at posterior scalp sites supports independent contributions of frontal and posterior association cortex to P300 generation.
在30名年龄在18岁至79岁之间的受试者中，研究了与体感任务相关的目标以及任务无关的新异（触觉和电击）刺激所诱发的事件相关脑电位（ERP）。目标刺激和新异刺激的P300潜伏期随年龄以相似的速率呈线性增加。P300波幅和头皮地形图也随年龄发生变化。随着年龄增长，无论是目标刺激还是新异刺激，额叶部位的P300波幅保持不变，而中央和顶叶部位的P300波幅则降低。目前的结果将听觉和视觉通道中所报道的与年龄相关的新异P300变化扩展到了体感系统。后头皮部位与年龄相关的波幅降低支持了额叶和后联合皮层对P300产生的独立作用。
