Santaniemi Merja, Kesäniemi Y Antero, Ukkola Olavi
Department of Internal Medicine and Biocenter Oulu, University of Oulu, PO Box 5000, 90014 Oulu, Finland.
Eur J Endocrinol. 2006 Nov;155(5):745-50. doi: 10.1530/eje.1.02287.
Adiponectin is an adipocytokine known to be decreased in obesity. It functions in glucose and fatty acid metabolism and also has an anti-inflammatory role in microvasculature. We wanted to investigate the role of adiponectin as a biomarker of metabolic syndrome (MS) and see how the plasma adiponectin levels relate to new criteria of MS proposed by the International Diabetes Federation.
Plasma adiponectin concentrations were measured from total of 1041 Finnish subjects with an ELISA - a novel method planned in our laboratory.
In both the sexes, the plasma adiponectin levels were lower in subjects with MS when compared with subjects with no diagnosis of MS (P< 0.001). Plasma adiponectin levels did not differ between subjects with National Cholesterol Education Program (ATPIII) and International Diabetes Federation-defined MS. Lower adiponectin levels were associated with different components of the MS and there was a trend towards decreasing adiponectin levels with an increasing number of components of MS in both the sexes. Subjects in the lowest adiponectin quartile had a significantly higher probability of having MS (P< 0.001), 4.4-fold in males and 7.5-fold in females, when compared with the corresponding individuals in the highest quartile. The probability increased in every lowering quartile of adiponectin level and was independent of body mass index.
We conclude that adiponectin levels correlate with most of the components of the MS and the metabolic cluster per se.
脂联素是一种脂肪细胞因子，已知在肥胖症中水平降低。它在葡萄糖和脂肪酸代谢中发挥作用，并且在微血管中也具有抗炎作用。我们想要研究脂联素作为代谢综合征（MS）生物标志物的作用，并了解血浆脂联素水平与国际糖尿病联盟提出的MS新诊断标准之间的关系。
采用酶联免疫吸附测定法（ELISA）测量了1041名芬兰受试者的血浆脂联素浓度，这是我们实验室设计的一种新方法。
无论男性还是女性，患有MS的受试者血浆脂联素水平均低于未诊断为MS的受试者（P<0.001）。根据美国国家胆固醇教育计划（ATPIII）标准和国际糖尿病联盟标准诊断为MS的受试者之间，血浆脂联素水平没有差异。较低的脂联素水平与MS的不同组分相关，并且在男性和女性中，随着MS组分数量的增加，脂联素水平均有下降趋势。与最高四分位数组的相应个体相比，处于最低脂联素四分位数组的受试者患MS的概率显著更高（P<0.001），男性为4.4倍，女性为～7.5倍。脂联素水平每降低一个四分位数，患病概率就增加，且与体重指数无关。
我们得出结论，脂联素水平与MS的大多数组分以及代谢簇本身相关。
