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[尿液细胞学检查与尿液标志物。对临床实践的意义]

[Urine cytology and urine markers. Significance for clinical practice].

作者信息

Tritschler S, Zaak D, Knuechel R, Stief C G

机构信息

Urologische Klinik und Poliklinik, Klinikum, Campus Grosshadern, Ludwig-Maximilians-Universität, München.

出版信息

Urologe A. 2006 Nov;45(11):W1441-7; quiz W1448. doi: 10.1007/s00120-006-1217-1.

DOI:10.1007/s00120-006-1217-1
PMID:17063350
Abstract

Urothelial carcinoma of the bladder is a frequent disease that can be identified timely by screening patients at high risk. Due to the high rate of disease recurrence, frequent follow-up procedures are necessary. For this purpose, cystoscopy is the standard procedure, and supplementary non-invasive procedures such as cytology or tumor marker tests are used. These tests have different advantages and disadvantages in terms of their sensitivities and specificities. Thus, they provide additional information, but are not able to replace cystoscopy as the standard instrument in the diagnosis of bladder cancer.

摘要

膀胱尿路上皮癌是一种常见疾病,通过对高危患者进行筛查可及时确诊。由于疾病复发率高,需要频繁进行后续检查。为此,膀胱镜检查是标准程序,同时还会使用细胞学检查或肿瘤标志物检测等辅助性非侵入性检查。这些检查在敏感性和特异性方面各有优缺点。因此,它们能提供额外信息,但无法取代膀胱镜检查作为膀胱癌诊断的标准手段。

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本文引用的文献

1
Validation of the diagnostic value of NMP22 BladderChek test as a marker for bladder cancer by photodynamic diagnosis.通过光动力诊断验证NMP22膀胱检测作为膀胱癌标志物的诊断价值。
Eur Urol. 2007 Feb;51(2):403-7; discussion 407-8. doi: 10.1016/j.eururo.2006.08.001. Epub 2006 Aug 15.
2
Multiprobe fluorescence in situ hybridisation: prognostic perspectives in superficial bladder cancer.多探针荧光原位杂交:浅表性膀胱癌的预后前景
J Clin Pathol. 2006 Sep;59(9):984-7. doi: 10.1136/jcp.2005.035394.
3
An international telecytologic quiz on urinary cytology reveals educational deficits and absence of a commonly used classification system.
一项关于尿液细胞学的国际远程细胞学测验揭示了教育缺陷以及常用分类系统的缺失。
Am J Clin Pathol. 2006 Aug;126(2):294-301. doi: 10.1309/6396-QUBU-6HEJ-BMPL.
4
Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas.FGFR3 突变作为非肌层浸润性尿路上皮膀胱癌预后因素的前瞻性研究。
J Clin Oncol. 2006 Aug 1;24(22):3664-71. doi: 10.1200/JCO.2005.05.1771.
5
uCyt+ test: alternative to cystoscopy for less-invasive follow-up of patients with low risk of urothelial carcinoma.尿细胞阳性(uCyt+)检测:用于低风险尿路上皮癌患者微创随访的膀胱镜检查替代方法。
Urology. 2006 May;67(5):950-4. doi: 10.1016/j.urology.2005.11.057.
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Improved detection and treatment of bladder cancer using hexaminolevulinate imaging: a prospective, phase III multicenter study.使用六氨基乙酰丙酸成像改善膀胱癌的检测和治疗:一项前瞻性III期多中心研究。
J Urol. 2005 Sep;174(3):862-6; discussion 866. doi: 10.1097/01.ju.0000169257.19841.2a.
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Diagnosis of urothelial carcinoma of the bladder using fluorescence endoscopy.使用荧光内镜诊断膀胱尿路上皮癌。
BJU Int. 2005 Aug;96(2):217-22. doi: 10.1111/j.1464-410X.2005.05604.x.
8
Urine markers for bladder cancer surveillance: a systematic review.用于膀胱癌监测的尿液标志物:一项系统评价。
Eur Urol. 2005 Jun;47(6):736-48. doi: 10.1016/j.eururo.2005.03.014. Epub 2005 Mar 23.
9
The role of urinary cytology for detection of bladder cancer.尿细胞学检查在膀胱癌检测中的作用。
Eur J Surg Oncol. 2005 Apr;31(3):304-8. doi: 10.1016/j.ejso.2004.12.008.
10
Urinary markers of bladder carcinoma.膀胱癌的尿液标志物。
Clin Chim Acta. 2004 Feb;340(1-2):57-65. doi: 10.1016/j.cccn.2003.11.008.