Chu Yueng-Hsiang, Wu Chin-Chen, Wang Hsing-Won
Graduate Institute of Medical Sciences, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Am J Rhinol. 2006 Sep-Oct;20(5):471-5. doi: 10.2500/ajr.2006.20.2942.
Exposure to cold causes cutaneous vasoconstriction to reduce body heat loss, while the nasal cavity warms up the inspired cold air. This suggests cooling might evoke a different response in nasal mucosa blood vessels than in cutaneous blood vessels. Thus, the aim of this study was to evaluate the effect of cooling (to 24 degrees C) on the vascular response of isolated nasal mucosa.
An in vitro isometric contraction of nasal mucosa excised from patients suffered from chronic nasal congestion was continuously recorded. Either electrical field stimulation (EFS) or exogenous norepinephrine (NE) was applied to the turbinate mucosa strip at 37 and 24 degrees C, and the influence of cooling (to 24 degrees C) was evaluated.
EFS (1, 2, 4, and 8 Hz) produced frequency-dependent contractions at 37 and 24 degrees C. Cooling did not alter the magnitude but significantly prolonged the duration of EFS-induced contraction. Exogenous NE (10(-8) to 10(-4) M) produced concentration-dependent contractions at 37 and 24 degrees C. Cooling significantly enhanced the contractile responses evoked by NE between 3 x 10(-6) and 1 x 10(-4) M.
Cooling (to 24 degrees C) prolonged the EFS-induced and enhanced NE (3 x 10(-6) to 1 x 10(-4) M)-induced contraction of isolated human nasal mucosa.
暴露于寒冷环境会导致皮肤血管收缩以减少身体热量散失，而鼻腔则会使吸入的冷空气升温。这表明降温可能会在鼻腔黏膜血管中引发与皮肤血管不同的反应。因此，本研究的目的是评估降温（至24摄氏度）对离体鼻腔黏膜血管反应的影响。
持续记录从患有慢性鼻充血患者身上切除的鼻腔黏膜的体外等长收缩情况。在37摄氏度和24摄氏度下，对鼻甲黏膜条施加电场刺激（EFS）或外源性去甲肾上腺素（NE），并评估降温（至24摄氏度）的影响。
EFS（1、2、4和8赫兹）在37摄氏度和24摄氏度下产生频率依赖性收缩。降温并未改变收缩幅度，但显著延长了EFS诱导收缩的持续时间。外源性NE（10^-8至10^-4摩尔）在37摄氏度和24摄氏度下产生浓度依赖性收缩。降温显著增强了3×10^-6至1×10^-4摩尔NE所引发的收缩反应。
降温（至24摄氏度）延长了EFS诱导的离体人鼻腔黏膜收缩，并增强了NE（3×10^-6至1×10^-4摩尔）诱导的收缩。
