希腊西北部肺炎链球菌的血清型分布及其对疫苗接种计划的影响。
Serotype distribution of Streptococcus pneumoniae in north-western Greece and implications for a vaccination programme.
作者信息
Levidiotou Stamatina, Vrioni Georgia, Tzanakaki Georgina, Pappa Christina, Gesouli Helen, Gartzonika Constantina, Papamichail Dimitrios, Kremastinou Jenny
机构信息
Department of Microbiology, Medical School, University of Ioannina, Ioannina, Greece.
出版信息
FEMS Immunol Med Microbiol. 2006 Nov;48(2):179-82. doi: 10.1111/j.1574-695X.2006.00126.x.
Serotypes and antibiotic sensitivities were determined for 338 strains of Streptococcus pneumoniae from children of north-western Greece with invasive pneumococcal disease (IPD), acute otitis media (AOM) and nasopharyngeal carriage. The most common serotypes among the isolates from IPD were 14 and 19F, while 3, 19F, 9V and 14 were the major cause of AOM. In these groups, the heptavalent conjugate vaccine for pneumococci (7vPCV) seems to cover 90.5% of the serotypes isolated from children less than 2 years old. Serotypes 23F and 6B were the most prevalent in carrier strains. Overall, 23.7% of the isolates were penicillin nonsusceptible (PNS), 97% were fully susceptible to cefotaxime, 29% were resistant to erythromycin, 11.2% to co-trimoxazole and 1.2% to clindamycin.
对来自希腊西北部患有侵袭性肺炎球菌疾病（IPD）、急性中耳炎（AOM）和鼻咽部携带肺炎链球菌的儿童的338株肺炎链球菌进行了血清型和抗生素敏感性测定。IPD分离株中最常见的血清型是14型和19F型，而3型、19F型、9V型和14型是AOM的主要病因。在这些组中，七价肺炎球菌结合疫苗（7vPCV）似乎覆盖了从2岁以下儿童中分离出的90.5%的血清型。23F型和6B型是携带菌株中最常见的血清型。总体而言，23.7%的分离株对青霉素不敏感（PNS），97%对头孢噻肟完全敏感，29%对红霉素耐药，11.2%对复方新诺明耐药，1.2%对克林霉素耐药。
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