Chang Kiki, Adleman Nancy, Wagner Christopher, Barnea-Goraly Naama, Garrett Amy
Stanford University School of Medicine, CA 94305-5540, USA.
Dev Psychopathol. 2006 Fall;18(4):1133-46. doi: 10.1017/S0954579406060548.
There is a great need for discovery of biological markers that could be used diagnostically for pediatric onset disorders, particularly those with potentially confusing phenomenology such as pediatric-onset bipolar disorder (BD). Obtaining these markers would help overcome current subjective diagnostic techniques of relying on parent and child interview and symptomatic history. Brain imaging may be the most logical choice for a diagnostic tool, and certain neurobiological abnormalities have already been found in pediatric BD. However, much work remains to be done before neuroimaging can be used reliably to diagnose this disorder, and because of the nature of BD and the limitations of imaging technology and technique, neuroimaging will likely at most be only a diagnostic aide in the near future. In this paper we discuss the characteristics of pediatric BD that complicate the use of biological markers as diagnostic tools, how neuroimaging techniques have been used to study pediatric BD so far, and the limitations and potential of such techniques for future diagnostic use.
迫切需要发现可用于诊断儿童期起病疾病的生物标志物，尤其是那些具有潜在混淆现象学的疾病，如儿童期起病的双相情感障碍（BD）。获得这些标志物将有助于克服目前依赖家长和儿童访谈及症状史的主观诊断技术。脑成像可能是诊断工具的最合理选择，并且在儿童双相情感障碍中已经发现了某些神经生物学异常。然而，在神经成像能够可靠地用于诊断这种疾病之前，仍有许多工作要做，而且由于双相情感障碍的性质以及成像技术和方法的局限性，神经成像在不久的将来最多可能只是一种诊断辅助手段。在本文中，我们讨论了儿童双相情感障碍的特征，这些特征使生物标志物作为诊断工具的使用变得复杂，到目前为止神经成像技术是如何用于研究儿童双相情感障碍的，以及这些技术在未来诊断应用中的局限性和潜力。
