Department of Medicine, Division of Infectious Diseases, 1959 NE Pacific, Box 356523, University of Washington, Seattle, WA 98195, USA.
Curr Infect Dis Rep. 2006 Nov;8(6):465-72. doi: 10.1007/s11908-006-0021-9.
Urinary tract infection (UTI) is a common clinical syndrome in women. Most UTIs are caused by Escherichia coli. UTI has become a productive and accessible model system for studying the molecular details of how bacteria interact with mucosal surfaces and the nature of the host response. Important advances in the past year include the discovery of new virulence determinants; better understanding the pathogenic role of the ubiquitous motility organelle, the flagellum; and defining aspects of coordinate regulation of virulence determinants in the pathogenesis of UTI.
尿路感染（UTI）是女性常见的临床综合征。大多数 UTI 是由大肠杆菌引起的。UTI 已成为研究细菌与粘膜表面相互作用的分子细节以及宿主反应性质的富有成效和易于研究的模型系统。过去一年的重要进展包括发现新的毒力决定因素；更好地理解普遍存在的运动器官——鞭毛在致病中的作用；以及定义 UTI 发病机制中毒力决定因素协调调控的某些方面。
