O'Sullivan Anthony J, Kriketos Adamandia D, Martin Allison, Brown Mark A
Department of Medicine, University of New South Wales and St. George Hospital, Sydney, Australia.
Hypertens Pregnancy. 2006;25(3):193-203. doi: 10.1080/10641950600912976.
The aim of this study was to quantify adiponectin levels in women with normal and hypertensive pregnancies to determine whether there is an independent association, while controlling for body fat and insulin sensitivity.
A cross-sectional study was conducted in the following categories: 12 normotensive non-pregnant women, 10 normotensive, 12 gestational hypertensive, 13 essential hypertensive, and 12 preeclamptic women. All subjects underwent measurements of body fat by bio-impedance analysis and blood sampling.
Percentage of body fat and insulin resistance were greater in all pregnant groups compared with non-pregnant women. Adiponectin concentrations were significantly lower in women with normal pregnancies (18.6 +/- 1.4 microg/mL, p = 0.02) compared with non-pregnant women (24.0 +/- 1.5 microg/mL). However, adiponectin levels were not significantly different among normal pregnancy, gestational hypertension (19.0 +/- 3.1 microg/mL), essential hypertension (24.0 +/- 3.7 microg/mL) and pre-eclampsia (22.4 +/- 2.5 microg/mL) groups. Adiponectin levels were inversely related to percent body fat and insulin resistance. When adiponectin levels were corrected for percent body fat and insulin resistance, no significant differences were seen among the study groups.
Adiponectin levels are decreased in normal pregnancy, however this difference disappears when adiponectin levels are corrected for the pregnancy-related increases in body fat and insulin resistance. Adiponectin levels are not altered significantly in states of hypertension in pregnancy compared with normal pregnancy.
本研究旨在对正常妊娠和高血压妊娠女性的脂联素水平进行量化，以确定在控制体脂和胰岛素敏感性的情况下是否存在独立关联。
进行了一项横断面研究，研究对象分为以下几类：12名血压正常的未孕女性、10名血压正常的妊娠女性、12名妊娠高血压女性、13名原发性高血压女性和12名先兆子痫女性。所有受试者均通过生物电阻抗分析测量体脂并采集血样。
与未孕女性相比，所有妊娠组的体脂百分比和胰岛素抵抗均更高。与未孕女性（24.0±1.5微克/毫升）相比，正常妊娠女性的脂联素浓度显著降低（18.6±1.4微克/毫升，p = 0.02）。然而，正常妊娠、妊娠高血压（19.0±3.1微克/毫升）、原发性高血压（24.0±3.7微克/毫升）和先兆子痫（22.4±2.5微克/毫升）组之间的脂联素水平无显著差异。脂联素水平与体脂百分比和胰岛素抵抗呈负相关。当对脂联素水平进行体脂百分比和胰岛素抵抗校正后，各研究组之间未见显著差异。
正常妊娠时脂联素水平降低，但在对脂联素水平进行与妊娠相关的体脂和胰岛素抵抗增加校正后，这种差异消失。与正常妊娠相比，妊娠高血压状态下脂联素水平无显著改变。
