Department of Clinical Biochemistry, Medical School, University of Athens, Attikon General University Hospital, Chaidari, Athens, Greece.
Metabolism. 2011 Nov;60(11):1539-44. doi: 10.1016/j.metabol.2011.03.021. Epub 2011 May 31.
Conditions resulting in insulin resistance, as well as metabolic, immune, and angiogenic perturbations, have been associated with an increased risk of preeclampsia (PE). Our purpose was to assess whether the adipose tissue-secreted hormones adiponectin, which has immune-modulating, metabolic, and angiogenic properties, and leptin, which reflects overall fat mass, are associated with PE risk. We performed a case-control design study within a hospital-based cohort of 368 pregnant women (106 with PE and 262 controls; mean age, 26.6 ± 6.8 years; mean gestational age at admission, 38.2 ± 2.8 weeks) between March 2005 and August 2007 at the Hospital of Pennsylvania University. Serum adiponectin and leptin were measured by radioimmunoassay. Statistical analysis of data was performed using simple and multiple regression analyses. No significant differences in adiponectin or leptin levels between preeclamptic and control pregnant women emerged in univariate analyses (P = .57 and P = .15, respectively). Among preeclamptic women, there were also no differences in adipokines between those with mild and severe disease. Serum adiponectin and leptin were not associated with higher risk of PE before and after adjustment for maternal age, race, primigravida, smoking status, body mass index at screening, gestational age at admission, history of PE, chronic hypertension, and gestational diabetes (odds ratio, 0.93; 95% confidence interval, 0.83-1.04 and odds ratio, 1; 95% confidence interval, 0.97-1.03, respectively). Maternal serum adiponectin and leptin levels, drawn at the time of PE diagnosis, were not associated with PE.
胰岛素抵抗以及代谢、免疫和血管生成紊乱等情况与先兆子痫（PE）风险增加相关。我们的目的是评估脂肪组织分泌的激素脂联素（具有免疫调节、代谢和血管生成特性）和瘦素（反映总体脂肪量）是否与 PE 风险相关。我们在宾夕法尼亚大学医院的一个基于医院的队列中进行了病例对照设计研究，该队列包括 368 名孕妇（106 名患有 PE，262 名对照；平均年龄 26.6±6.8 岁；入院时的平均孕龄为 38.2±2.8 周），时间为 2005 年 3 月至 2007 年 8 月。采用放射免疫分析法测量血清脂联素和瘦素。使用简单和多元回归分析对数据进行统计分析。在单变量分析中，PE 孕妇和对照组孕妇的脂联素和瘦素水平没有差异（P=.57 和 P=.15）。在 PE 妇女中，轻度和重度疾病的脂联素也没有差异。在调整了母亲年龄、种族、初产妇、吸烟状况、筛查时的体重指数、入院时的孕龄、PE 病史、慢性高血压和妊娠期糖尿病后，血清脂联素和瘦素与 PE 的风险增加无关（比值比，0.93；95%置信区间，0.83-1.04 和比值比，1；95%置信区间，0.97-1.03）。PE 诊断时母体血清脂联素和瘦素水平与 PE 无关。
