使用手术伤口感染模型来确定新型外用抗生素瑞他帕林的有效给药方案。
Use of the surgical wound infection model to determine the efficacious dosing regimen of retapamulin, a novel topical antibiotic.
作者信息
Rittenhouse Stephen, Singley Christine, Hoover Jennifer, Page Roni, Payne David
机构信息
Department of Microbiology Research, MMPD CEDD, GlaxoSmithKline Pharmaceuticals, 1250 S. Collegeville Rd, Collegeville, PA 19426-0989, USA.
出版信息
Antimicrob Agents Chemother. 2006 Nov;50(11):3886-8. doi: 10.1128/AAC.00183-06.
Abstract
The effect of topically applied retapamulin ointment was evaluated using various dosing regimens in the Staphylococcus aureus and Streptococcus pyogenes wound infection model. Retapamulin (1%, wt/wt) was efficacious using twice-daily (b.i.d.) applications for 4 or 5 days. These data underpinned the decision to evaluate 1% retapamulin b.i.d. in clinical trials.
摘要
在金黄色葡萄球菌和化脓性链球菌伤口感染模型中，使用不同给药方案评估了局部应用瑞他帕林软膏的效果。瑞他帕林（1%，重量/重量）每日两次（bid）给药4或5天有效。这些数据为在临床试验中评估1%瑞他帕林每日两次给药提供了依据。
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