Lagerkvist B, Ekelund H
Scand J Infect Dis. 1975;7(2):81-4. doi: 10.3109/inf.1975.7.issue-2.01.
Three cytarabine-treated infants and children with herpes simplex encephalitis are presented. The effect of the treatment was excellent in 2 cases. One boy who had a CP syndrome died. It is assumed that the treatment with cytarabine should be started as early as possible with a dosage of 3 mg/kg body weight given intravenously once a day in a single injection for 5 days. No serious side effects have been noted. The advantage of cytarabine over idoxuridine, especially when treating small children and herpetic infections in the central nervous system, are emphasized.
本文报告了3例接受阿糖胞苷治疗的单纯疱疹性脑炎婴幼儿及儿童。2例治疗效果极佳。1例患有脑性瘫痪综合征的男孩死亡。据推测，阿糖胞苷治疗应尽早开始，剂量为3mg/kg体重，每日静脉注射1次，单次给药，共5天。未观察到严重副作用。强调了阿糖胞苷相对于碘苷的优势，尤其是在治疗小儿及中枢神经系统疱疹感染时。
