聚合酶链反应用于诊断单纯疱疹病毒性脑炎的评估。
Evaluation of the polymerase chain reaction for diagnosis of herpes simplex virus encephalitis.
作者信息
Puchhammer-Stöckl E, Heinz F X, Kundi M, Popow-Kraupp T, Grimm G, Millner M M, Kunz C
机构信息
Institute of Virology, University of Vienna, Austria.
出版信息
J Clin Microbiol. 1993 Jan;31(1):146-8. doi: 10.1128/jcm.31.1.146-148.1993.
Abstract
Cerebrospinal fluid samples from 257 patients with suspected herpes simplex virus encephalitis were prospectively analyzed by herpes simplex virus polymerase chain reaction. The polymerase chain reaction indicated herpes simplex virus encephalitis in 9 serologically proven cases and in 14 additional patients. Increased polymerase chain reaction signals were observed together with more severe neurological symptoms (P < 0.01) and within the first days of acyclovir treatment (P < 0.05).
摘要
对257例疑似单纯疱疹病毒性脑炎患者的脑脊液样本进行前瞻性单纯疱疹病毒聚合酶链反应分析。聚合酶链反应在9例血清学确诊病例及另外14例患者中显示为单纯疱疹病毒性脑炎。观察到聚合酶链反应信号增加与更严重的神经症状相关（P<0.01），且在阿昔洛韦治疗的最初几天内出现（P<0.05）。
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