厚皮香鲜叶中的抗氧化酚类物质。

Antioxidative phenolics from the fresh leaves of Ternstroemia japonica.

作者信息

Jo Youngmi, Kim Minkyung, Shin Myung Hee, Chung Hae Young, Jung Jee H, Im Kwang Sik

机构信息

College of Pharmacy, Pusan National University, Busan 609-735, Korea.

出版信息

J Nat Prod. 2006 Oct;69(10):1399-403. doi: 10.1021/np060096w.

DOI:10.1021/np060096w

PMID:17067150

Abstract

Six new phenylethanoid glucosides, ternstrosides A-F (1-6), a new kaempferol derivative (7), and eight known compounds were isolated from the fresh leaves of Ternstroemia japonica. The structures were elucidated by 1D and 2D NMR spectroscopic analyses. Compounds 1-7 showed potent antioxidative activity in three different tests, with IC50 values in the range 3.26-6.50 microM in the hydroxyl radical (*OH) inhibitory activity test, 33.29-82.21 microM in the total ROS (reactive oxygen species) inhibitory activity test, and 1.14-13.53 microM in the peroxynitrite (ONOO-) scavenging activity test.

摘要

从厚皮香的新鲜叶片中分离出6个新的苯乙醇苷类化合物ternstrosides A - F（1 - 6）、1个新的山柰酚衍生物（7）以及8个已知化合物。通过一维和二维核磁共振光谱分析确定了这些化合物的结构。化合物1 - 7在三种不同的测试中均表现出较强的抗氧化活性，在羟基自由基（*OH）抑制活性测试中的IC50值范围为3.26 - 6.50微摩尔，在总活性氧（ROS）抑制活性测试中的IC50值范围为33.29 - 82.21微摩尔，在过氧亚硝酸根（ONOO-）清除活性测试中的IC50值范围为1.14 - 13.53微摩尔。