Jo Youngmi, Kim Minkyung, Shin Myung Hee, Chung Hae Young, Jung Jee H, Im Kwang Sik
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
J Nat Prod. 2006 Oct;69(10):1399-403. doi: 10.1021/np060096w.
Six new phenylethanoid glucosides, ternstrosides A-F (1-6), a new kaempferol derivative (7), and eight known compounds were isolated from the fresh leaves of Ternstroemia japonica. The structures were elucidated by 1D and 2D NMR spectroscopic analyses. Compounds 1-7 showed potent antioxidative activity in three different tests, with IC50 values in the range 3.26-6.50 microM in the hydroxyl radical (*OH) inhibitory activity test, 33.29-82.21 microM in the total ROS (reactive oxygen species) inhibitory activity test, and 1.14-13.53 microM in the peroxynitrite (ONOO-) scavenging activity test.
从厚皮香的新鲜叶片中分离出6个新的苯乙醇苷类化合物ternstrosides A - F（1 - 6）、1个新的山柰酚衍生物（7）以及8个已知化合物。通过一维和二维核磁共振光谱分析确定了这些化合物的结构。化合物1 - 7在三种不同的测试中均表现出较强的抗氧化活性，在羟基自由基（*OH）抑制活性测试中的IC50值范围为3.26 - 6.50微摩尔，在总活性氧（ROS）抑制活性测试中的IC50值范围为33.29 - 82.21微摩尔，在过氧亚硝酸根（ONOO-）清除活性测试中的IC50值范围为1.14 - 13.53微摩尔。
