Manzanaro Sonia, Salva Javier, de la Fuente Jesús Angel
Instituto Biomar, S.A., Polígono Industrial, Edificio CEEI, 24231 Onzonilla, León, Spain.
J Nat Prod. 2006 Oct;69(10):1485-7. doi: 10.1021/np0503698.
Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.
从被囊动物中分离出的四种不同类型的海洋天然化合物被发现可抑制人醛糖还原酶。它们都具有杂环系统的特征，并且结构中至少存在两个酚羟基。所测试的两种化合物显示出比已知的醛糖还原酶抑制剂索比尼尔高5/6倍的抑制效力。这些活性化合物的一个显著结构特征是缺乏目前常用抑制剂主要类别中常见的羧酸或螺环乙内酰脲。
