Humbert Patrick O, Dow Lukas E, Russell Sarah M
Cell Cycle & Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia.
Trends Cell Biol. 2006 Dec;16(12):622-30. doi: 10.1016/j.tcb.2006.10.005. Epub 2006 Oct 25.
The Par complex [consisting of Bazooka (also called Par3), Par6 and aPKC] is a well-described regulator of cell polarity whose role in many aspects of cell morphogenesis is under intense investigation. Recently, another set of proteins known as the Scribble complex (consisting of Scribble, Discs large and Lethal giant larvae) has also been shown to be important in polarity regulation in several settings. Here, we describe the current status of Scribble in polarity and review evidence from various model systems that indicates an essential but context-dependent role for the Scribble and Par complexes in directed cell migration. Based on the known interactions of Scribble and Par complexes with each other and with other signalling pathways, we propose models by which Par and Scribble might interact to regulate cell migration.
Par复合物（由Bazooka，也称为Par3、Par6和非典型蛋白激酶C组成）是一种已被充分描述的细胞极性调节因子，其在细胞形态发生诸多方面的作用正受到深入研究。最近，另一组被称为Scribble复合物（由Scribble、盘状大蛋白和致命巨幼虫蛋白组成）的蛋白质也已被证明在多种情况下的极性调节中很重要。在这里，我们描述了Scribble在极性方面的现状，并回顾了来自各种模型系统的证据，这些证据表明Scribble和Par复合物在定向细胞迁移中起着至关重要但依赖于背景的作用。基于Scribble和Par复合物彼此之间以及与其他信号通路的已知相互作用，我们提出了Par和Scribble可能相互作用以调节细胞迁移的模型。
