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在一种伴有严重胰岛素抵抗的特殊糖尿病综合征中，损害胰岛素受体结合的抗体。

Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.

作者信息

Flier J S, Kahn C R, Roth J, Bar R S

出版信息

Science. 1975 Oct 3;190(4209):63-5. doi: 10.1126/science.170678.

DOI:10.1126/science.170678
PMID:170678
Abstract

Six patients with a unique form of diabetes associated with extreme insulin resistance have markedly reduced insulin binding to specific receptors on their circulating monocytes. When normal insulin receptors were exposed to serum or immunoglobulin fractions from three of these patients in vitro the specific binding defect was reproduced.

摘要

六名患有与极端胰岛素抵抗相关的独特糖尿病形式的患者，其循环单核细胞上特定受体的胰岛素结合能力显著降低。当正常胰岛素受体在体外与其中三名患者的血清或免疫球蛋白组分接触时，会重现特异性结合缺陷。

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