Wellington Kevin W, Benner Steven A
Foundation for Applied Molecular Evolution, Gainesville, Florida 32604, USA.
Nucleosides Nucleotides Nucleic Acids. 2006;25(12):1309-33. doi: 10.1080/15257770600917013.
In this article, we focus on the synthesis of aryl C-glycosides via Heck coupling. It is organized based on the type of structures used in the assembly of the C-glycosides (also called C-nucleosides) with the following subsections: pyrimidine C-nucleosides, purine C-nucleosides, and monocyclic, bicyclic, and tetracyclic C-nucleosides. The reagents and conditions used for conducting the Heck coupling reactions are discussed. The subsequent conversion of the Heck products to the corresponding target molecules and the application of the target molecules are also described.
在本文中，我们聚焦于通过Heck偶联反应合成芳基C-糖苷。本文根据用于组装C-糖苷（也称为C-核苷）的结构类型进行组织，包括以下小节：嘧啶C-核苷、嘌呤C-核苷以及单环、双环和四环C-核苷。文中讨论了进行Heck偶联反应所使用的试剂和条件。还描述了Heck反应产物向相应目标分子的后续转化以及目标分子的应用。
