Mauri F A, Scampini S, Aldovini D, Ferrero S, Barbareschi M, Dalla Palma P
Department of Histopathology, S. Trinità Hospital, Borgomanero, Italy.
Pathologica. 1990 Sep-Oct;82(1081):487-92.
The present paper investigated the distribution of AgNOR in serous tumours of the ovary, with a particular attention to borderline lesion and carcinomas. AgNOR are classified as large AgNOR (LN) and small AgNOR (SN) and are counted separately in 100 nuclei for each tumor. Total number of AgNOR was also recorded (TN). The study shows that the mean values of LN, SN and TN increase from adenomas to borderline lesions and carcinomas, with highly significant differences (p less than 0.001). LN show the most impressive differences between borderline lesion and carcinomas, without overlap of values. The follow up of the patients is not long enough for any correlation between AgNOR counts and prognosis, but preliminary data suggest that high AgNOR counts in borderline tumors should be interpreted very cautiously, because they do not seem to have any correlation with a more aggressive behaviour.
本文研究了卵巢浆液性肿瘤中AgNOR的分布情况，特别关注了交界性病变和癌。AgNOR分为大AgNOR（LN）和小AgNOR（SN），对每个肿瘤的100个细胞核分别进行计数。同时记录AgNOR的总数（TN）。研究表明，从腺瘤到交界性病变和癌，LN、SN和TN的平均值逐渐升高，差异具有高度显著性（p小于0.001）。LN在交界性病变和癌之间显示出最显著的差异，数值无重叠。由于患者的随访时间不够长，无法确定AgNOR计数与预后之间的相关性，但初步数据表明，交界性肿瘤中高AgNOR计数的情况应非常谨慎地解读，因为它们似乎与更具侵袭性的行为无关。
