Ingle Ronald, Levin Jonathan, Polinder Krijn
Department of Family Medicine, University of Limpopo (Medunsa Campus), South Africa.
S Afr Med J. 2006 Sep;96(9):831-5.
To compare honey and IntraSite Gel as woundhealing agents, to record side-effects, gauge patient satisfaction and calculate the cost-effectiveness of the honey used.
A prospective, randomised, double-blind controlled trial was carried out among goldmine workers.
Outcome measures were healing times of shallow wounds and abrasions; side-effects; patient satisfaction with treatment; and amount of honey and IntraSite Gel used.
The mean healing times of shallow wounds treated with honey or with IntraSite Gel did not differ significantly (p = 0.75, 95% confidence interval (CI): -5.41; 7.49 days). When adjusted for wound size, the 2.8-day difference in favour of honey was not significant (p = 0.21, 95% CI: -2.41; 8.09). In the case of abrasions there was also no significant difference (p = 0.83, 95% CI: -4.98; 6.19 days). When adjusted for wound size, the difference of 0.22 days in favour of IntraSite Gel was not significant (p = 0.94, 95% CI: -5.72; 6.15.4). Of patients treated with honey, 27% and 10% respectively experienced itching and pain, and 2 experienced burning for a short time after application. Of patients treated with IntraSite Gel, 31% experienced itching. All patients in both treatment groups were either satisfied or extremely satisfied with treatment. The average cost of treatment per patient was R0.49 with honey and R12.03 with with IntraSite Gel.
A distinction should be made between shallow wounds and abrasions when wound healing is being measured. There was no evidence of a real difference between honey and IntraSite Gel as healing agents. Honey is a safe, satisfying and effective healing agent. Natural honey is extremely costeffective.
比较蜂蜜和安普贴凝胶作为伤口愈合剂的效果，记录副作用，评估患者满意度并计算所用蜂蜜的成本效益。
在金矿工人中进行了一项前瞻性、随机、双盲对照试验。
观察指标为浅伤口和擦伤的愈合时间、副作用、患者对治疗的满意度以及蜂蜜和安普贴凝胶的使用量。
用蜂蜜或安普贴凝胶治疗的浅伤口平均愈合时间无显著差异（p = 0.75，95%置信区间（CI）：-5.41；7.49天）。调整伤口大小后，蜂蜜治疗组比安普贴凝胶治疗组快2.8天的差异不显著（p = 0.21，95% CI：-2.41；8.09）。对于擦伤，两者也无显著差异（p = 0.83，95% CI：-4.98；6.19天）。调整伤口大小后，安普贴凝胶治疗组比蜂蜜治疗组快0.22天的差异不显著（p = 0.94，95% CI：-5.72；6.15）。用蜂蜜治疗的患者中，分别有27%和10%出现瘙痒和疼痛，2例在用药后短时间内有烧灼感。用安普贴凝胶治疗的患者中，31%出现瘙痒。两个治疗组的所有患者对治疗均满意或极其满意。蜂蜜治疗每位患者的平均成本为0.49兰特，安普贴凝胶为12.03兰特。
在测量伤口愈合时，应区分浅伤口和擦伤。没有证据表明蜂蜜和安普贴凝胶作为愈合剂存在实际差异。蜂蜜是一种安全、令人满意且有效的愈合剂。天然蜂蜜极具成本效益。
